It is not a problem today to buy Nolvadex, the drug is sold in almost every pharmacy, but its price may differ. Often, pharmacies are ready to offer low prices below for Nolvadex in case of sales. But these sales usually take place at online pharmacies, so you need to monitor their appearance.
What is Nolvadex
Doctors prescribe Nolvadex in cases of detecting malignant formations in the thoracic glands and genital organs of men and women. It includes non-steroidal substances possessing antiestrogenic action, which suppresses the growth of pathological cells, normalizes the hormonal background.
Nolvadex belongs to the group of antagonists of hormones and the like, has antiestrogenic action. This effect of the drug is achieved due to the content of active substance tamoxifen citrate in it, which binds estrogens in certain areas of the body and slows the progression of tumor growth.
Nolvadex is available only in tablet form. The main active substance of the drug is tamoxifen.
Pharmacodynamics and pharmacokinetics
Nolvadex is a non-steroidal substance and has antiestrogenic action. Such an effect is manifested by the binding of estrogens in specific regions. There is a depression of the receptors of autogenic hormones, slowing down the progress of tumor growth, which is stimulated by estrogens. After getting into the stomach and intestines, the substance is rapidly absorbed.
The maximum concentration of the component is observed in 4-7 hours after receiving, and the state of equilibrium occurs in 4-6 weeks. About 99% of the drug is bound to plasma proteins (albumins). Metabolism of the drug occurs in the liver, the drug is excreted in urine. Excretion is two-phase, the output lasts 14-28 hours for the first phase and 14 days for the second.
Indications for use
In the instructions for use, enclosed inside each pill with tablets contain information on indications of the use of the drug.
These include diseases and conditions: adjuvant breast cancer therapy in women; treating breast cancer with affected lymph nodes and metastases in men and women; breast cancer oncology in women; breast cancer in men after castration; cancer of the kidneys, ovaries, prostate gland; melanoma, carcinoma containing estrogen receptors.
How to take Nolvadex
In addition to treating breast cancer and endometrium, the drug can take bodybuilders to increase endurance and muscle efficacy. Depending on the destination, Nolvadex is characterized by dosage, mode of use, duration of therapy. Tablets are taken orally, washed with water. The dosage is determined by the physician individually, based on the patient’s condition and severity of the disease.
Treatment of breast cancer and endometrial cancer
In case of oncology of the mammary gland, the daily dose of Nolvadex is 20 mg, with the common form of the disease, the dosage will be 30-40 mg/day, and the maximum is 40 mg. The objective response to therapy is documented 4-10 weeks after the start of treatment, with metastases in bone tissue, the effect may appear a few months after the accumulation of the active substance.
The course of treatment continues until remission occurs and is determined by a physician. If necessary, the therapy is complemented by the administration of cytostatic drugs, radiation therapy methods. If a single dose of tablets is indicated, the dose is taken in the morning.
Application in bodybuilding
Due to the fact that tamoxifen raises the level of testosterone in the body, Nolvadex is used in sports and bodybuilding. Reception of the drug with a 20 mg ten-day course increases the level of male hormones in the blood by 42%, and after half a month the effect will be 83%. The goals of the use of Nolvadex are also an increase in muscle mass, relief, increase in total body weight or decrease in the concentration of fat, prevention of gynecomastia, accumulation of fluid, deposits of fat.
Nolvadex blocks the development of iron deficiency anemia, jaundice, liver dysfunction, masculinization in women. The medication is used for post-treatment therapy. The dose is selected individually (10-40 mg/day), taking less than 30 mg/day is not accompanied by side effects. The full course is seven packs of 30 pills.
The medicine is used with caution in the treatment of patients with kidney pathology, diabetes mellitus, ophthalmic diseases, thromboembolic lesions in history, leukopenia, thrombocytopenia, hypercalcemia;
prolonged drug intake requires constant monitoring of calcium, leukocytes, indicators of coagulation and platelet count in the blood, observation by an ophthalmologist for intracranial and ocular pressure;
It is unlikely that Nolvadex reduces the speed and concentration of attention, clarity of vision, therefore the medicine is allowed for use while driving and dangerous mechanisms.
Before treatment, patients undergo a thorough examination, pregnancy should be excluded. Women of childbearing age need to be protected safely throughout the course of treatment and three months after the end, to replace oral contraceptive pills with barrier contraceptives. The use of Nolvadex in pregnancy and breastfeeding is prohibited, it is a risk of hormonal abnormalities and development with the growth of the fetus or newborn baby.
Compatibility with alcohol
According to doctors, it is strictly forbidden to combine the use of the drug with alcohol, alcohol-based drinks, and Nolvadex. It leads to increased hepatic loading, the risk of poisoning and reduced drug efficacy.
These include: leukopenia, thrombocytopenia, neutropenia, pancytopenia; hot flushes, vaginal, uterine bleeding, menstrual irregularities, vaginal discharge, itching of the genitals, vulva; endometrial hyperplasia, polyps, endometriosis, endometrial cancer; cessation of menstruation, reversible cystic ovarian edema and cyst development; impotence, loss of libido, myasthenia; nausea, vomiting, anorexia, loss of taste, constipation, diarrhea, increased acidity of gastric juice; reduction of visual acuity, corneal opacity, cataract, retinopathy; pancreatitis, hypertriglyceridemia, fatty liver infiltration, hypertrophy; cholestasis, hepatitis, alopecia (baldness), multiform erythema; hypersensitivity, angioneurotic edema; bullous pemphigoid; thrombosis, embolism of the pulmonary artery.
According to doctors, there were no acute cases of overdose with Nolvadex. Manifestations of poisoning with the drug are heightened side effects. To eliminate them, you should urgently seek medical advice.